Healing the Addicted Brain
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How Does Addiction Affect the Brain?
Oddly, in spite of the opposing nature of their effects, both stimulants (cocaine and amphetamines) and CNS depressants (opioids and alcohol) are similar in their primary mechanisms: all the drugs in these categories affect neurotransmitters, the chemicals that transmit signals in the brain. Over time, ingestion of drugs alters the delicate process of neurotransmission, eventually habituating the brain to the drug. The main neurotransmitter involved in addiction is dopamine, which is responsible for the triggering the pleasure/reward circuit as well as movement, attention, and memory. Additionally, dopamine plays a critical role in motivation. When an individual first experiments with a drug, the brain’s chemistry rebalances itself as the drug wears off and the substances are flushed from the body. Over time, however, the drug will create changes in cellular structure and function, and neurotransmission is affected. When a drug disrupts the pleasure/reward cycle, the addicted brain is no longer able to adequately find pleasure in normal enjoyable activities, a condition called anhedonia. The addict, of course, does not experience brain chemistry and electrical signals jumping across synapses; it experiences desire—at first for pleasure, and eventually simply to feel normal.Article author
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