Side effects of Acelofenac and Paracetamol with Serratiopeptidase

Paracetamol is a popular analgesic (pain-controlling) and antipyretic (fever-reducing) drug that is used for the relief of headaches, fever, and minor aches and pains, such as pain in joints and muscles. It is a major ingredient in numerous cold and flu medications and many prescription analgesics. When used responsibly in standard doses, it is considered effective and safe, but because of its wide availability and narrow therapeutic index, accidental or deliberate overdoses are not uncommon.use of a pain-killing drug like acetaminophen is just one of a multitude of approaches to dealing with pain, which has varied causes and influences. Among non-drug treatments and preventative actions are acupuncture, homeopathy, naturopathy, chiropractic, dietary changes, and ayurveda. Given the power of the mind, there are also various mind-body therapies, such as hypnosis, biofeedback, meditation, and visualization. Certainly the key to dealing with pain is understanding the cause, as well as trying to prevent the pain before it occurs, or recognizing the symptoms and addressing the problem early.

Overdose or continuous use of paracetamol leads to paracetamol toxicity. This toxicity normally results into liver injury. It is also one of the most common causes of poisoning all over world. Many people who develop paracetamol toxicity may show no symptoms at all in the first 24 hours after the overdose of paracetamol tablet. Others, however, may initially experience nonspecific complaints like vague abdominal pain and nausea. As the toxicity of paracetamol tablet increases, signs of liver failure like low blood sugar, low blood pH, easy bleeding, and hepatic encephalopathymay may develop.The risk of paracetamol toxicity increases with excessive alcohol intake, fasting or anorexia nervosa, and also with the use of certain drugs like isoniazid.

Paracetamol is derived from coal tar. It belongs to the class of drugs known as "aniline analgesics." The gravity of the side effects can be understood by the fact that it is the only such drug still in use today. In June 2009, an advisory committee of FDA recommended that new restrictions should be placed on paracetamol to help protect people from the potential toxic effects. However, as till March 2010, the FDA has not implemented these recommendations.

* High dose-usage (greater than 2,000 mg per day) of paracetamol increases the risk of upper gastrointestinal complications like stomach bleeding.
* Heavy use of paracetamol (300 grams a year or 1 g per day on average) has been linked to a condition known as 'Small Indented and Calcified Kidneys' (SICK).
* A study in 2008 on long term side effects of paracetamol tablets in children found that administering paracetamol for fever in the first year of life was linked with an increase in the incidence of asthmatic symptoms at 6–7 years. It also stated that use of paracetamol (both in the first year of life and in children aged 6–7 years) was associated with an increased incidence of rhinoconjunctivitis and eczema.
* Paracetamol used excessively damages multiple organs, particularly the liver and kidney where toxicity from paracetamol is not from the drug itself but from one of its metabolites, N-acetyl-p-benzoquinoneimine (NAPQI).
* Paracetamol hepatotoxicity is the most common cause of acute liver failure- one of the most dangerous side effects of paracetamol.
* Habitual use of paracetamol leads to decrease in threshold for pain in a person. This means that the endurance level for pain reduces in that person.

The paracetamol tablets are used to cure minor aches and pain related to common cold, flu, toothaches, arthritis, menstrual cramps and other conditions. It is generally used by people who are sensitive or allergic to aspirin. However, Paracetamol tablets used in excess (overdose or continuous use) can prove fatal due to its many side effects some of which are very dangerous leading to failure of liver and kidney and ultimately death.